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Brand Name: Hydrocodone/APAP

The following product information is not intended to replace the physician's or manufacturer's instructions.
Most Common Medical Uses
Hydrocodone relieves pain. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. Together, acetaminophen and hydrocodone are most commonly used to relieve moderate-to-severe pain. Acetaminophen and hydrocodone may also be used for purposes other than those listed here.

How to Take This Medication
Take acetaminophen and hydrocodone exactly as directed by your doctor. Take each dose with a full glass of water. Take acetaminophen and hydrocodone with food or milk if it upsets your stomach. Never take more of this medication than is prescribed for you. Too much acetaminophen and hydrocodone could be very harmful. Do not stop taking acetaminophen and hydrocodone suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.

Possible Side Effects

Stop taking acetaminophen and hydrocodone and seek emergency medical attention if you experience any of the following: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); slow, weak breathing; seizures; cold, clammy skin; severe weakness or dizziness; unconsciousness; yellowing of the skin or eyes; or unusual fatigue, bleeding, or bruising. Less serious side effects may be more likely to occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


Hydrocodone is habit forming and should only be used under close supervision if you have an alcohol or drug addiction. Before taking this medication, tell your doctor if you have kidney disease; liver disease; asthma; urinary retention; an enlarged prostate; hypothyroidism; seizures epilepsy; gallbladder disease; a head injury; or Addison's disease. Do not take this medication without first talking to your doctor if you are pregnant or breast-feeding a baby. If you are younger than 18 years of age or older than 60 years of age, you may be more likely to experience side effects from acetaminophen and hydrocodone therapy. Use extra caution.

Drug Interactions
Do not take acetaminophen and hydrocodone if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result. The most serious interactions affecting acetaminophen and hydrocodone are with those drugs that also cause sedation. Numerous drugs may lead to dangerous sedation if taken with acetaminophen and hydrocodone: Talk to your doctor and pharmacist before taking any prescription or over the counter medicines. Many other drugs contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications.

Missed Dose
Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.


Store at room temperature away from moisture and heat. Keep this and all medications out of the reach of children.

Avoid alcohol while taking acetaminophen and hydrocodone. Alcohol will greatly increase the drowsiness and dizziness caused by acetaminophen and hydrocodone and could be dangerous. Also, acetaminophen can damage your liver if you drink three or more alcoholic beverages a day. Avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medications also may cause dangerous sedation. Do not share acetaminophen and hydrocodone with others for whom it was not prescribed, since they may have a problem that is not effectively treated by this drug.

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